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Unlocking the secrets of ageing hidden in blood cells

Blood cells have their own agenda for ageing and other cells don't have a say in it

07-Feb-2019

Key points from article :

Human blood cells have a biological clock that could control human ageing.

Measured cellular age in blood cells transplanted from healthy donors to leukaemia patients.

Cells retained their intrinsic age nearly two decades after transplantation.

DNA methylation age of transplanted blood reflected the age of the donor, after so many years.

Ageing clock of blood cells is cell-intrinsic, and not set by interactions with other cell types.

Next step is to identify mechanisms that can change this ageing clock.

Research by Case Western Reserve University School of Medicine, published in Aging Cell.

Mentioned in this article:

Click on resource name for more details.

Case Comprehensive Cancer Center

Cancer Center of Case Western University

Case Western Reserve University School of Medicine

Medical school based in Cleveland, Ohio

Shigemi Matsuyama

Associate Professor in the Department of Medicine of Case Western Reserve University School of Medicine

Steve Horvath

Professor of Human Genetics & Biostatistics at UCLA

Topics mentioned on this page:
Biological Age, Epigenetics