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Protein that regulates muscle function in ageing discovered

Blocking it improved muscle strength & function while endurance was also boosted in mice


Key points from article :

Blocking a single protein in old mice restores muscular mass & strength, and helps them run longer on treadmill.

While increasing the expression of the protein in young mice causes their muscles to atrophy and weaken.

The protein, 15-PGDH, is elevated in old muscle and other old tissues.

Similar pattern of 15-PGDH expression was found in human muscle tissues.

Effect of a small molecule that blocks 15-PGDH was observed in old and young animals.

“In old mice, even just partially inhibiting 15-PGDH restored prostaglandin E2 to physiological levels found in younger mice” - Helen Blau, author.

“The muscle fibres in these mice grew larger, and were stronger, than before the treatment."

Treated animals were also able to run longer on a treadmill than untreated animals.

"Considering that humans lose about 10% of muscle strength per decade after about age 50, this is quite remarkable.”

Research by Stanford University published in Science.

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Helen Blau

Leading regenerative medicine biologist at Stanford with a focus on stem cells

Science Magazine

Academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals

Stanford University School of Medicine

Medical school that improves health through discoveries and innovation in health care, education and research

Topics mentioned on this page:
Rejuvenation, Musculoskeletal