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XPO1 inhibition increases autophagy and lifespan


Key points from article :

Reducing the expression of XPO1 led to an increased concentration of TFEB.

This was associated with an increase in autophagy markers.

Lifespan of nematodes was increased by 15 to 45%.

Similar effect with selective inhibitors of nuclear export (SINE).

Treating human cells with XPO1 inhibition saw an increase in markers of authophagic activity.

The study was published in the Cell Reports journal.

This treatment could be used to alleviate neurodegeneration and disease progression

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Private Ivy League research university in Rhode Island.


Journal publishing research papers across a broad range of disciplines within the life sciences.


Assistant Professor of Molecular Biology, Cell Biology and Biochemistry at Brown University.