Key points from article :
Reducing the expression of XPO1 led to an increased concentration of TFEB.
This was associated with an increase in autophagy markers.
Lifespan of nematodes was increased by 15 to 45%.
Similar effect with selective inhibitors of nuclear export (SINE).
Treating human cells with XPO1 inhibition saw an increase in markers of authophagic activity.
The study was published in the Cell Reports journal.