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Successful replacement of neurons lost in Parkinson's disease

13-May-2020

Key points from article :

Reprogramming a patient's own skin cells to replace cells in the brain, shown feasible.

These are for cells progressively lost in Parkinson's disease called dopaminergic neurons.

This overcomes barriers associated with use of cells from another individual.

Team reprogrammed a 69-year-old patient's skin cells to embryo-like pluripotent stem cells (iPSCs).

And then differentiated them to take on the characteristics of dopaminergic neurons.

Gained FDA approval for single-patient, expanded-access protocol to implant cells in patient's brain.

A novel minimally invasive neurosurgical implantation procedure was done.

2 years later, imaging tests show transplanted cells are alive and functioning correctly.

Patient has enjoyed improvements in his daily routine and quality of life.

By team of investigators from McLean Hospital and Massachusetts General Hospital (MGH).

Published in New England Journal of Medicine.

New therapeutic personalized strategy could bring back movement to those suffering

Mentioned in this article:

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Bob Carter

Chief of Neurosurgery at MGH

Jeffrey Schweitzer

Neurosurgeon, MGH

Kwang-Soo Kim

South Korean neuroscientist, McLean Hospital

Massachusetts General Hospital (MGH)

Largest teaching hospital of Harvard Medical School located in Boston

McLean Hospital

Psychiatric hospital, affiliate of Harvard Medical School

Michael G. Kaplitt

Neurosurgeon, Weill Cornell Medicine

The New England Journal of Medicine

Scientific Journal devoted to medical research.

Todd Herrington

Neurologist, MGH

Weill Cornell Medicine

Biomedical research unit and medical school of Cornell University.