This enzyme helps reverse age-related neurodegeneration in mice


Team discovered that HDAC1 enzyme is critical for repairing age-related DNA damage.
They engineered mice in which they could knock out HDAC1 specifically in neurons.
For the first several months of the mice's lives, there were no discernable differences.
As the mice aged, differences became more apparent.
HDAC1 loss led to a specific type of DNA damage called 8-oxo-guanine lesions.
An enzyme called OGG1 is responsible for repairing this type of oxidative DNA damage.
Researchers found that HDAC1 is needed to activate OGG1.
When HDAC1 is missing, OGG1 fails to turn on and DNA damage goes unrepaired.
Exifone, drug used to treat two different mouse models of Alzheimer's.
Indeed, it reduced the levels of oxidative DNA damage in the brain.
It also improved the mice's cognitive functions, including memory.
Research by MIT neuroscientists, published in Nature Communications.

Sheds light to potential treatments for age-related cognitive decline, Alzheimer's

Mentioned in this article:

Resource Harvard Medical School - Institution for medical education.

Resource Li-Huei Tsai - Neuroscientist, Director of MIT's Picower Institute for Learning and Memory

Resource Massachusetts Institute of Technology (MIT)

Resource Nature Communications - Journal covering all topics in physics, chemistry, and biology.

Resource Ping-Chieh Pao - Research Scientist, MIT

Resource Stephen Haggarty - Professor, Neuroscientist, Department of Neurology, Harvard Medical School

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