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Macrophages trigger stem cells for wound repair and regeneration


Key points from article :

Researchers after six years of experiments on fish isolated a signal that turns on the cells.

In mice, a signalling chemical prompts stem cells to begin knitting together.

Pharma companies to test it as a treatment for muscular dystrophy and ageing.

“It fully restored the architecture of the muscle” - Peter Currie, director of Australian Regenerative Medicine Institute.

Scientists cautioned the research was a long way away from the clinic.

Using multiphoton microscopy, able to film the movement of cells around a wound on a zebrafish.

Macrophages were sending signals to the stem cells using a signalling hormone called NAMPT.

Giving high doses may supercharge the process.

When removed the immune cells, the wounds did not heal.

When applied NAMPT paste to a wound on a mouse, it substantially increased healing speed.

“Opens up the door for more investigation and better quality treatment,” - Ashish Diwan, director of Spine Service.

Research by Monash University published in Nature.

Macrophages and stem cell interaction promotes muscle repair in zebrafish and mice models

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Director of Spine Service at the Department of Orthopaedic Surgery, St. George Hospital


Public Research university.


Scientific journal covering research from a variety of academic disciplines, mostly in science and technology


Professor and Director of Research, Australian Regenerative Medicine Institute at Monash University