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Macrophages trigger stem cells for wound repair and regeneration

11-Feb-2021

Key points from article :

Researchers after six years of experiments on fish isolated a signal that turns on the cells.

In mice, a signalling chemical prompts stem cells to begin knitting together.

Pharma companies to test it as a treatment for muscular dystrophy and ageing.

“It fully restored the architecture of the muscle” - Peter Currie, director of Australian Regenerative Medicine Institute.

Scientists cautioned the research was a long way away from the clinic.

Using multiphoton microscopy, able to film the movement of cells around a wound on a zebrafish.

Macrophages were sending signals to the stem cells using a signalling hormone called NAMPT.

Giving high doses may supercharge the process.

When removed the immune cells, the wounds did not heal.

When applied NAMPT paste to a wound on a mouse, it substantially increased healing speed.

“Opens up the door for more investigation and better quality treatment,” - Ashish Diwan, director of Spine Service.

Research by Monash University published in Nature.

Macrophages and stem cell interaction promotes muscle repair in zebrafish and mice models

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Academic

Director of Spine Service at the Department of Orthopaedic Surgery, St. George Hospital

Academia

Public Research university.

Academic

Professor and Director of Research, Australian Regenerative Medicine Institute at Monash University