The what, where and how sirtuins work at the cellular level to impact ageing
Fundamental ageing research used to be a slow, unexciting, area of academia, with all the big names and money looking at specific diseases. But now that people have realised that most age-related diseases have a shared cause (aging, who'd have thought it?) it's becoming big business. Private money is being invested in biotech start-ups, which is great, but there is still plenty of basic (and by that I don't mean simple) research to do to increase our understanding of the very complex products and processes of ageing.Sometimes I prefer to call this "anti-ageing research" - because nobody is researching how to speed it up!
A note on spelling - Ageing or Aging?
According to Cambridge Dictionary: UK = ageing, US = aging
Being a UK-based club, the preference is to spell it with an "e" - but as most publications use the US version (and it's quicker to type!), realistically, it is used interchangeably throughout the site.
Click on resource name for more details.
Ageing Research Blog Posts
Effects of intermittent fasting: An exploration
Live Forever Club - 31-Jan-2023
12 months of IF results in a range of biomarker improvements, but no significant reduction in inflammatory markersRead more...
Open genes-comprehensive database of genes associated with aging and longevity
Lifespan.io (LEAF) - 24-Jan-2023
Open gene database simplifies the search for potential aging therapy targetsRead more...
Heart's biological age can be delayed by 10 years by an anti-aging mutant gene discovered
Medical Xpress - 23-Jan-2023
Healthy mutant gene can reverse the decline of heart performance in older peopleRead more...
Dissociation of longevity targeted cell reprogram and somatic identity loss: An exploration
Live Forever Club - 17-Jan-2023
Most genes regulating cellular rejuvenation were not related to the increased occurrence of cancerRead more...
Gut microbiome linked to brain damage and neurodegeneration in mice
EurekAlert! - 12-Jan-2023
Modifying gut microbiota with antibiotics reduced inflammation and tau-linked damageRead more...