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Procyanidin, a senotherapeutic compound from grape seed extends lifespan in mice

14-Dec-2021

Key points from article :

A new senomorphic compound from grape seed extract (GSE) enhances chemotherapy and prolongs lifespan & healthspan in mice.

GSE shows senomorphic effect - preserves senescent cells but alleviates harmful aspects of their phenotype.

At higher concentrations, GSE eliminated up to 80% of senescent cells without affecting the viability of normal cells.

A component called procyanidin C1 (PCC1) in GSE ​eliminated most of the cancer cells.

Mitoxantrone-PCCC1 combo remarkably enhanced tumor regression (55.2% reduction in tumor size).

In young mice, senescence-induced decline in physical abilities was largely reversed.

Bi-weekly PCC1 treatment in mice for four months eliminated senescent cells and increased physical function and longevity.

Lived almost 10% longer, and median post-treatment lifespan increased by 64%.

Supports that senolytics can effectively slow aging, even when administered later in life.

Study led by Sun Yu from CAS published in the journal Nature.

Improved survival via eliminating old cells - potential candidate to slowdown ageing

Mentioned in this article:

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Institute

National scientific institution for natural sciences and high technology development.

Journal

Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Academic

Professor in Shanghai Institute of Nutrition and Health at Chinese Academy of Sciences