Join the club for FREE to access the whole archive and other member benefits.

Procyanidin, a senotherapeutic compound from grape seed extends lifespan in mice

Improved survival via eliminating old cells - potential candidate to slowdown ageing


Key points from article :

A new senomorphic compound from grape seed extract (GSE) enhances chemotherapy and prolongs lifespan & healthspan in mice.

GSE shows senomorphic effect - preserves senescent cells but alleviates harmful aspects of their phenotype.

At higher concentrations, GSE eliminated up to 80% of senescent cells without affecting the viability of normal cells.

A component called procyanidin C1 (PCC1) in GSE ​eliminated most of the cancer cells.

Mitoxantrone-PCCC1 combo remarkably enhanced tumor regression (55.2% reduction in tumor size).

In young mice, senescence-induced decline in physical abilities was largely reversed.

Bi-weekly PCC1 treatment in mice for four months eliminated senescent cells and increased physical function and longevity.

Lived almost 10% longer, and median post-treatment lifespan increased by 64%.

Supports that senolytics can effectively slow aging, even when administered later in life.

Study led by Sun Yu from CAS published in the journal Nature.

Mentioned in this article:

Click on resource name for more details.

Chinese Academy of Sciences (CAS)

National scientific institution for natural sciences and high technology development.


Scientific journal covering research from a variety of academic disciplines, mostly in science and technology

Sun Yu

Professor in Shanghai Institute of Nutrition and Health at Chinese Academy of Sciences

Topics mentioned on this page:
Senescent Cells, Supplements