Key points from article :
Metformin is a well-studied drug for hyperglycaemia & a credible longevity drug - lowers risk of cancer, heart disease and dementia.
But metformin can interfere with exercise metabolism - Berberine and Gynostemma are botanical alternatives.
Best indicator of metabolic health is blood glucose levels 2 hours after a meal.
People who are active & not overweight shouldn't worry about statistics in the “prediabetic” range.
Josh Mitteldorf used a wearable continuous blood glucose monitor - Freestyle Libre.
Glucose rose after a meal and to a lesser extent, when he exercised.
Taking metformin with a meal reduced the glucose spike after the meal. Berberine did not have this immediate effect.
Downward trend over 10 days was due to gradual loosening of the monitor.
Noticed a natural variability of blood sugar uncorrelated with either food or exercise.
Plans to drop Metformin and take low doses of berberine and Gynostemma with a light evening meal and regular walks.
