Key points from article :
João Pedro de Magalhães presented at Ending Age-Related Diseases 2019.
He studies computational and experimental approaches to ageing at the University of Liverpool.
Setup GenAge - the ageing gene database.
Identifies over 2,000 genes in animal models that have an impact on longevity.
One gene knocked out in worms results in 10x life expectancy.
Ageing process is plastic in animals.
DrugAge database of ageing-related drugs has identified over 500 drugs/compounds which significantly extend lifespan in model organisms.
LongevityMap = Human Longevity Genetic Variants.
What works on animals may not work in humans as we’re long-lived already.
We know a lot more about cell senescence in animals than in humans.
