Review on the relationship between senescence and bone marrow cancer
Cancers, by their nature, create senescent cells (SCs) and share a complex relationship.
SCs, when in excess, secrete pro-inflammatory compounds.
These facilitates further cancer growth rather than preventing it.
Evidence that cancers (i.e. leukemia) may even actively provoke nearby cells to become senescent.
Review focused on the role of senescence in the aging bone marrow (BM) microenvironment.
BM disorders are age-related diseases, highly dependent on BM microenvironment.
Despite advances in drug development the prognosis particularly for older patients remains poor.
Senolytic drugs may be of value for cancer treatment and other age-related diseases.
New treatment targets needed to impair tumor survival, reduce treatment resistance.
Review published in Frontiers in Oncology.
Mentioned in this article:
Frontiers in Oncology - Peer-reviewed research, cancer research,
Judith Campisi - Professor of biogerontology and Biochemist.