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Caution Regarding CRISPR Gene Therapies

Newly found lack of precision of CRISPR delays plans for human trials


Key points from article :

CRISPR can cause more unintended damage than thought.

Enzyme cuts a cell’s DNA and relies on the cell to reconnect.

Can cause large deletions or rearrangements of DNA around the target site.

Fears this kind of damage to DNA could lead to cancer.

Has gone unnoticed as looking for small mutations.

"Changes in the DNA have been seriously underestimated”

The study was published in Nature Biotechnology journal.

Mentioned in this article:

Click on resource name for more details.

Allan Bradley

Director and Chief Scientific Officer at Kymab Ltd.

Nature Biotechnology

Journal providing information from all areas of biotechnology.

Wellcome Sanger Institute

Center for genomic discovery.

Topics mentioned on this page:
Gene Therapy