Key points from article :
Cortex Discovery has achieved a significant breakthrough in the field of longevity research with the development of CortexW1, the first AI-discovered drug shown to extend the lifespan of a whole organism. The compound was tested on Caenorhabditis elegans (a microscopic worm) and demonstrated an impressive 33% increase in the median lifespan of the organism. This discovery was made possible through a deep learning-based QSAR (Quantitative Structure-Activity Relationship) model, which was trained using human data targeting the mTOR pathway—a key regulator of autophagy, a process that helps cells remove damaged components.
The AI-driven approach screened numerous compounds, with four selected for lab testing. CortexW1 emerged as the most promising candidate, validated using Ora Biomedical's WormBot-AI, a high-throughput testing platform for longevity interventions. This result highlights the potential of AI in revolutionizing drug discovery for age-related diseases and extending lifespan, opening up exciting possibilities for future research in human longevity.
This achievement marks a milestone for AI-powered drug development, as Cortex Discovery pushes the boundaries of what is possible in longevity research by combining cutting-edge AI with biological science.
