Join the club for FREE to access the whole archive and other member benefits.

Recalibration of signalling factors to more youthful levels in the blood


Key points from article :

Rejuvenation might be achieved by the calibration of age-related changes signals found in the blood.

Tissue ageing could be reversed in a matter of weeks with the beneficial signals from the younger animal.

Protein TGF-β1 was found to prevent stem cells from repairing tissue properly in old and young mice.

Scientists were able to reduce TGF-β1 levels and increase oxytocin.

Changing the molecule levels in the blood resulted in promoted rejuvenation and increased neurogenesis.

Recalibration of these signalling factors back reduced the p16 biomarker of cellular senescence.

The study was published in journal Aging.

Adjusting the levels of just two molecules in the blood could lead to significant rejuvenation

Mentioned in this article:

Tap on icon for description, click on resource name for more details.


Bio-medical journal covering research on all aspects of gerontology


Professor of Bioengineering at Berkeley University of California.


Lecturer in Department of Bioengineering at Berkley University of California.