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Senescent Cells

Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.

Senescent cells are aging cells that have stopped dividing but do not die off as they should. Instead, they linger in the body, secreting harmful chemicals (senescence associated secretory phenotype, or SASP) that can lead to inflammation and damage surrounding tissues. This process is thought to contribute to various age-related diseases, including cancer, cardiovascular disease, and neurodegenerative conditions, as well as to the overall aging process itself. The accumulation of senescent cells is believed to impair tissue function and promote a range of chronic conditions, thereby negatively impacting health and potentially reducing life expectancy.

To combat the adverse effects of senescent cells, researchers are developing senotherapeutics, drugs designed to target and manage these cells in several ways. 

Senolytics are drugs that selectively induce death in senescent cells. By eliminating senescent cells, senolytics aim to reduce inflammation and improve tissue function. Various compounds, including dasatinib, quercetin, and navitoclax, have shown promise in preclinical and some early clinical trials.

Senomorphics, on the other hand, do not kill senescent cells. Instead, they suppress the SASP produced by these cells or alter their function to mitigate their detrimental effects on the body. This approach aims to reduce inflammation and tissue damage without necessarily removing the senescent cells.

Senoblockers are designed to interfere with the signaling pathways that allow cells to enter or maintain the senescent state. By blocking these pathways, senoblockers aim to prevent the accumulation of senescent cells or revert them to a less harmful state. 

The development and use of these therapies face challenges, including ensuring specificity to target only senescent cells without harming normal cells, and understanding the long-term effects of altering the body's natural aging processes. Despite these challenges, the field of senotherapeutics holds significant promise for improving human health and longevity.

Senescent Cells News

Scientists found a way to restart cell division safely and reverse ageing in mice

Scientists found a way to restart cell division safely and reverse ageing in mice

Live Forever Club - 16-Jan-2025

Treated mice lived longer, moved better, and remembered more

Breaking new ground in anti-ageing science: Bonerge’s 108-person clinical trial

Breaking new ground in anti-ageing science: Bonerge’s 108-person clinical trial

Business Wire - 08-Jan-2025

Synergy of Fisetin, Urolithin A, and Ergothioneine for anti-ageing

The hidden role of senescent cells in ageing and organ dysfunction

The hidden role of senescent cells in ageing and organ dysfunction

Live Forever Club - 16-Dec-2024

The study introduces a "senescence atlas" mapping the distribution of these cells

Senescence halts cell division but can promote inflammation, aiding cancer growth

Senescence halts cell division but can promote inflammation, aiding cancer growth

Live Forever Club - 24-Nov-2024

Therapies targeting senescence cells show promise for controlling cancer progression

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Senescent Cells Resources

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London Longevity: Targeting Senescence to Extend Health and Lifespan (w/ Daniel Munoz-Espín)

27-Jan-2025

London Futurists event about Senescence with Daniel Munoz-Espín (London, UK)

Leveraging the power of senolytics to eliminate senescence cells

Longevity Technology discusses senescent cells with Steve Matheson, CEO of Combilytics (YouTube)

Robin Mansukhani at ARDD2024: Restoring Immune Function to Ablate Senescent Cells ... Aging

Robin Mansukhani discusses restoring immune function to remove senescent cells

Adam Antebi at ARDD2024: Insights into stem cell longevity, rejuvenation & senescence from diapause

Adam Antebi explores stem cell longevity, rejuvenation, and senescence via diapause

Rejuveron

Company that develops and invests in drugs and technologies which prolong human lifespan.

Vertical Longevity Pharma

Vertical Longevity Pharma develops senolytic therapies to enhance longevity

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Senescent Cells