Senescent Cells

Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.

Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.

Draft page - more coming soon.


Company Rubedo Life Sciences - Extending Health Span and Reverting Age-Related Diseases.

Company CellAge - working with the aim to develop synthetic promoters that would be able to specifically identify senescent cells

Company Biotein - Company in the field of longevity and biotechnology that aims to provide a novel way to eradicate senescent cells.

Publisher UNITY Biotechnology - Biotechnology company devoted to research of restoring human health.

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Recent News

Labiotech gathers feedback from European biotechs on Unity failure

Labiotech - 28-Aug-2020

General feeling that failures are bound to happen - but that their approaches can succeed


Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial

Fight Aging! - 18-Aug-2020

Disappointing first result - but lessons learnt and plenty of other strategies available


Exercise reduces inflammation caused by SASP but not the number of senescent cells

Fight Aging! - 31-Jul-2020

Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining

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