Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.
Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.
Draft page - more coming soon.
Rubedo Life Sciences - Extending Health Span and Reverting Age-Related Diseases.
CellAge - working with the aim to develop synthetic promoters that would be able to specifically identify senescent cells
Biotein - Company in the field of longevity and biotechnology that aims to provide a novel way to eradicate senescent cells.
UNITY Biotechnology - Biotechnology company devoted to research of restoring human health.More Senescent Cells resources
Labiotech gathers feedback from European biotechs on Unity failure
Labiotech - 28-Aug-2020
General feeling that failures are bound to happen - but that their approaches can succeedRead more...
Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial
Fight Aging! - 18-Aug-2020
Disappointing first result - but lessons learnt and plenty of other strategies availableRead more...
Exercise reduces inflammation caused by SASP but not the number of senescent cells
Fight Aging! - 31-Jul-2020
Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remainingRead more...