Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.
Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.
Draft page - more coming soon.
Biotein - Company in the field of longevity and biotechnology that aims to provide a novel way to eradicate senescent cells.
UNITY Biotechnology - Biotechnology company devoted to research of restoring human health.
Senolytics may have the potential to treat asthma
Life Extension Advocacy Foundation (LEAF) - 07-Apr-2020
Will senolytics become the panacea to the whole Pandora's box by 100 years into future?Read more...
Positive feedback look identified with ATM via NF-κB pathway back to cellular senescence
Life Extension Advocacy Foundation (LEAF) - 02-Apr-2020
As always, it's complicated, but controlling levels of ATM could be part of a therapy to combat ageingRead more...
Review on the relationship between senescence and bone marrow cancer
Life Extension Advocacy Foundation (LEAF) - 23-Mar-2020
How senescence can fuel cancer development and how malignant cells induce senescenceRead more...