Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.
Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.
Draft page - more coming soon.
Click on resource name for more details.
Cellular Senescence Network (SenNet)
Consortium to comprehensively identify and characterize the differences in senescent cells across the body
Biotechnology company producing therapy that targets and destroys senescent cells.
Senolytic Therapeutics (Senolytx)
Pharmaceutical company that develops a novel class of medicines by targeting damaged cells.
Biopharmaceutical company focused on discovering and developing drugs against aging disorders and cancer.
Endurance Exercise Training May Help Prevent Accumulation of Senescent Cells in Colon Mucosa
Live Forever Club - 20-Mar-2023
Age-related increase in inflammatory markers p16 and IL-6 was not observed in endurance athletesRead more...
AKL Therapeutics’ investigational senotherapeutics drug APPA beneficial for oral osteoarthritis
Longevity Technology - 20-Mar-2023
Senescent cells have become one of the most promising targets for healthy aging researchRead more...
Reversal of cell senescence using low frequency ultrasound
Live Forever Club - 27-Jan-2023
Novel therapy killed some senescent cells, rejuvenated others, without harming healthy cellsRead more...
Cellular Senescence Network (SenNet) to identify and characterize senescent cells
Nature Aging - 20-Dec-2022
Grand plan includes creation of imaging datasets, new tools, techniques, and biomarker panelsRead more...
Targeting senescent cells could be a useful approach for slowing/treating Alzheimer’s disease
Salk Institute - 01-Dec-2022
How senescent neurons lead to Alzheimer’s disease, effect on removal and drugs needed for therapyRead more...