Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.
Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.
Draft page - more coming soon.
OncoSenX targets solid tumours with senolytics
Life Extension Advocacy Foundation (LEAF) - 22-Oct-2019
Phase 1 clinical trial starting early 2020Read more...
Cardiac glycosides may play a role as broad spectrum senolytics
Medical Research Council London Institute of Medical Sciences - 21-Oct-2019
Is it really possible to develop a drug without side effects?Read more...
Is senescent cell clearance a zero sum game?
SENS Research Foundation - 06-Oct-2019
Research suggests senolytic treatments will be beneficial for at least a few decadesRead more...