Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.
Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.
Draft page - more coming soon.
UNITY Biotechnologies Selects a New Senolytic CandidateLEAF - 14-Jan-2019
Very early days but good to have more senolytics in the pipeline
Senolytics for IPF human clinical trial results releasedLEAF - 07-Jan-2019
Physical improvements recorded, but pulmonary function was unchcanged
Fisetin destroys senescent cells, but safe dosage not determined yetLEAF - 26-Dec-2018
Includes table of fisetin content in range of fruits and vegetables