Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.
Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.
Draft page - more coming soon.
Synthetic antibodies able to target senescent cellsUniversity of Leicester - 06-Mar-2019
nanoMIPs could improve the specificity of senolyticsRead more...
UNITY Biotechnology expands trial of osteoarthritis senolyticUNITY Biotechnology - 22-Jan-2019
Initial results must be promising to enrol more patients at highest dosageRead more...
UNITY Biotechnologies Selects a New Senolytic CandidateLife Extension Advocacy Foundation (LEAF) - 14-Jan-2019
Very early days but good to have more senolytics in the pipelineRead more...