Senescent Cells
Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.
Senescent cells have stopped dividing and, even worse, secrete tens of biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors. This Senescence Associated Secretory Phenotype (SASP) can induce senescence in neighbouring cells and is associated with many age-related diseases.
Draft page - more coming soon.
Resources
Click on resource name for more details.
Leveraging the power of senolytics to eliminate senescence cells
Longevity Technology discusses senescent cells with Steve Matheson, CEO of Combilytics (YouTube)
Cellular Senescence Network (SenNet)
Consortium to comprehensively identify and characterize the differences in senescent cells across the body
SIWA Therapeutics
Biotechnology company producing therapy that targets and destroys senescent cells.
Senolytic Therapeutics (Senolytx)
Pharmaceutical company that develops a novel class of medicines by targeting damaged cells.
Recent News
Phase I trial shows early promise in clearing senescent cells in Alzheimer's
Wake Forest Baptist Health - 07-Sep-2023
The treatment was well-tolerated with no significant changes in brain function
Read more...Senolytics have gender-specific effects on ageing in young mice
Lifespan.io (LEAF) - 30-Aug-2023
More research is needed to determine the safety and efficacy of senolytics in humans
Read more...AI identifies new senolytics that could treat age-related diseases
Lifespan.io (LEAF) - 09-Aug-2023
Three natural compounds identified, paving the way for new treatments
Read more...Experimental vaccine promises to slow down or prevent Alzheimer's in mice
American Heart Association - 30-Jul-2023
Vaccine not only reduced inflammation, but also improved behavior and awareness in mice
Read more...Tiny sea creature unlocks the secrets of healing and aging
Phys.org - 30-Jun-2023
Insights on the evolution of ageing and may help advance regenerative medicine
Read more...