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Senescent Cells

Senescent cell clearance could be one of the big treatments to at least slow down one of the underlying causes of aging.

Senescent cells are aging cells that have stopped dividing but do not die off as they should. Instead, they linger in the body, secreting harmful chemicals (senescence associated secretory phenotype, or SASP) that can lead to inflammation and damage surrounding tissues. This process is thought to contribute to various age-related diseases, including cancer, cardiovascular disease, and neurodegenerative conditions, as well as to the overall aging process itself. The accumulation of senescent cells is believed to impair tissue function and promote a range of chronic conditions, thereby negatively impacting health and potentially reducing life expectancy.

To combat the adverse effects of senescent cells, researchers are developing senotherapeutics, drugs designed to target and manage these cells in several ways. 

Senolytics are drugs that selectively induce death in senescent cells. By eliminating senescent cells, senolytics aim to reduce inflammation and improve tissue function. Various compounds, including dasatinib, quercetin, and navitoclax, have shown promise in preclinical and some early clinical trials.

Senomorphics, on the other hand, do not kill senescent cells. Instead, they suppress the SASP produced by these cells or alter their function to mitigate their detrimental effects on the body. This approach aims to reduce inflammation and tissue damage without necessarily removing the senescent cells.

Senoblockers are designed to interfere with the signaling pathways that allow cells to enter or maintain the senescent state. By blocking these pathways, senoblockers aim to prevent the accumulation of senescent cells or revert them to a less harmful state. 

The development and use of these therapies face challenges, including ensuring specificity to target only senescent cells without harming normal cells, and understanding the long-term effects of altering the body's natural aging processes. Despite these challenges, the field of senotherapeutics holds significant promise for improving human health and longevity.

Senescent Cells News

Researchers explore the potential of sound waves for anti-ageing

Lifespan.io (LEAF) - 09-Feb-2024

Originally used to fight cancer, sound waves surprisingly revive old cells

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Mice who sipped green tea all their lives lived longer and stayed healthier

Live Forever Club - 04-Feb-2024

Green tea improved gut health and boosted the immune system in mice

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Having too much iron in your body can damage organs like lungs and kidneys

Live Forever Club - 28-Jan-2024

This could impact how much iron we get from food or supplements

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New immune cells can recognise and eliminate a specific protein on ageing cells

Live Forever Club - 25-Jan-2024

In mice, this therapy was shown to reduce the number of senescent cells

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A new method called FAST studies cellular ageing in cultured cells

Live Forever Club - 18-Jan-2024

FAST is precise and works with different cell types and microscopes

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Senescent Cells Resources

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SENISCA

University of Exeter spinout developing senotherapeutic interventions through modulation of dysregulated RNA splicing

Leveraging the power of senolytics to eliminate senescence cells

Longevity Technology discusses senescent cells with Steve Matheson, CEO of Combilytics (YouTube)

Cellular Senescence Network (SenNet)

Consortium to comprehensively identify and characterize the differences in senescent cells across the body

Rejuveron

Company that develops and invests in drugs and technologies which prolong human lifespan.

Rubedo Life Sciences

Extending Health Span and Reverting Age-Related Diseases.

SIWA Therapeutics

Biotechnology company producing therapy that targets and destroys senescent cells.

Senolytic Therapeutics (Senolytx)

Pharmaceutical company that develops a novel class of medicines by targeting damaged cells.

Cleara Biotech

Cleara is developing therapeutics to eliminate senescent cells.

UNITY Biotechnology

Biotechnology company devoted to research of restoring human health

Dorian Therapeutics

Anti-aging company developing senoblockers.

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