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Lifespan of middle-aged mice increased by a third with telomerase gene therapy

Treatment used proprietary CMV vector which is able to deliver multiple genes into the nucleus


Key points from article :

BioViva's patent pending CMV vector delivered genes that increased life spans over 41% in a mouse model.

Two gene therapies were evaluated: telomerase reverse transcriptase and follistatin.

Median lifespans in the treated mice were respectively lengthened by 41.4% and 32.5%.

Treatment did not begin until the mice were 18 months old, equivalent to 56 human years. 

Therapies also mitigated age-related hair loss, improved blood glucose tolerance, improved physical coordination, reduced sarcopenia, and reversed signs of mitochondrial dysfunction. 

CMV has low immunogenicity and can be engineered to carry multiple genes. 

Telomerase group did not show an increased risk of cancer.

Intranasal administration was just as effective as injection.

CMV can deliver genes into the nucleus - an ability that current non-viral delivery systems lack. 

"The proprietary delivery method ... lets us target complex aging associated non-communicable diseases the level of the cell" - Elizabeth Parrish, CEO of BioViva.

Research by Rutgers New Jersey Medical School (led by Hua Zhu, Liz Parrish and George Church) published in the Proceedings of the National Academy of Science (PNAS). 

Mentioned in this article:

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Bioviva Science

Gene therapy innovation leaders developing platforms to treat severe genetic disorders and cellular aging

George Church

Harvard Professor and Founder

Hua Zhu

Associate Professor in Department of Microbiology at Rutgers New Jersey Medical School.

Liz Parrish

Founder and CEO of BioViva

Proceedings of the National Academy of Sciences (PNAS)

Multidisciplinary scientific journal, official journal of the National Academy of Sciences

Topics mentioned on this page:
Telomeres, Gene Therapy