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Advancements in organ biofabrication may lead to build human heart for transplant


Key points from article :

By recreating the helical structure of heart muscles, researchers improve understanding of how the heart beats.

The heart, unlike other organs, cannot repair itself after injury. 

A new method of additive textile manufacturing, Focused Rotary Jet Spinning (FRJS) was used.

The first biohybrid model of human ventricles with helically aligned beating cardiac cells has been developed.

“Our goal was to build a model ... importance of the heart’s helical structure,” said John Zimmerman, co-first author of the paper.   

“With FRJS, we can recreate those complex structures forming single and even four chambered ventricle structures”,  Huibin Chang, co-first author.

The research is published in Science and took place at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS).

Helical structure of heart muscles helps understand the functioning of heart

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Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS)

Engineering school within Harvard University's Faculty of Arts and Sciences.

Huibin Chang

Research Associate in Bioengineering at Harvard University

John Zimmerman

Postdoctoral Fellow- Disease Biophysics Group, at Harvard University, SEAS


Peer-reviewed academic online journal of the American Association for the Advancement of Science (AAAS)