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Stem cell transplantation repairs stroke-injured rat brains

New possibility on restoring injured neural circuitry in humans after stroke

08-Apr-2020

Key points from article :

Restoring mobility and sensation of touch in stroke-afflicted rats, successful.

Done by reprogramming human skin cells to become nerve cells.

Then transplanted into rat cerebral cortex (most often damaged after stroke).

6 months post-transplantation, new cells had repaired stroke damage.

Tracking techniques used to verify if brain connections were properly formed.

Fibers from transplanted cells have grown to the other side of the brain.

Confirming that they really have connected correctly in the damaged nerve circuits.

Future hopes of replacing dead nerve cells with new healthy ones in stroke patients.

Further studies to see how transplanted cells affect opposite hemisphere, memory.

Possible side effects will be determined in case of future clinical use.

Mentioned in this article:

Click on resource name for more details.

Olle Lindvall

Professor at Lund University, Chairman of the Division of Neurology at the University Hospital, Lund

Proceedings of the National Academy of Sciences (PNAS)

Multidisciplinary scientific journal, official journal of the National Academy of Sciences

Sara Palma-Tortosa

Researcher, Post-doctoral Fellowship at Lund University

Zaal Kokaia

Georgian-Soviet-Swedish biologist, Professor, Lund University

Topics mentioned on this page:
Stroke, Stem Cells