Key points from article :
A quality control system removes damaged and potentially toxic proteins from their surroundings.
Recognize buildup of misfolded proteins that can aggregate together outside the cells.
Clusterin can bind to misfolded extracellular proteins and prevent them from aggregating.
Clusterin and heparan sulfate join to bring misfolded proteins into cells for degradation.
May lead to new therapeutic targets for neurodegenerative disorders, including Alzheimer's.
Research by Chiba University, Japan published in Journal of Cell Biology.
