Irina summarised a recent paper on the Conboys plasma dilution experiments, this one focussed on cognition.
Compared cognitive decline in mice given young blood and those give neutral blood exchange (NBE).
Cognition tests based on how long young mice pay attention to new (textured) objects.
Old mice performed as young mice after a single treatment.
Saw decreased neuroinflammation and improved neurogenesis not observed using ABT-263 senolytic.
Proteins levels that drop with age don't have to be added back in - naturally re-elevated after NBE.
Conboys' conclusion - do not need factors in young blood for rejuvenation.
Ability to produce proteins doesn't disappear from our genome.
Plasma dilution cannot be achieved by donating blood then drinking lots of water! someone did ask ;)
Technical problem with mice is that their blood vessels are tiny so difficult to insert tubes multiple times.
Just a matter of funding and clinical support to perform large-scale human clinical trials.
Research paper available (open access) from GeroScience: https://link.springer.com/article/10.1007/s11357-020-00297-8
