Key points from article :
Epigenetic signatures of Werner syndrome (WRN) occur early in life.
These are in contrast and distinct from normal epigenetic aging processes.
Forms of cellular damage and their proportions are different.
Epithelial to non-epithelial cancers ratio in WRN is 1:1, in usual aging it is 10:1.
>90% of DMRs in WRN were not affected by aging.
DMRs were enriched in genes associated with transcription factor activity.
Hypothesis: WRN, based upon aberrant controls of varied genetic loci expressions.
Some of which are plausibly related to clinical phenotypes of WRN.
Finding reinforces concept that organism composition greatly affects functioning and lifespan.
Published in Aging.
