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Pro-repair microenvironment after injury is favored by targeting senescent cells


Key points from article :

Mammals often suffer from whole-body paralysis following recovery from spinal cord injuries.

Fish can recover from injury relatively rapidly in comparison to mammals.

Reason is due to formation of a complex scar associated with chronic inflammation.

Which produces a cellular microenvironment blocking tissue repair.

Researcher administered drugs that target specific cellular components to improve recovery after injury.

In mammals, upon spinal cord injury, they observed that cells start to accumulate at the lesion periphery.

Known as senescent cells with specific features and markers, we can call them "zombie cells".

Where growth and division are interrupted, but the normal cell death program is not activated.

Leonor Saude says that "... accumulation of these cells at the injury periphery is cleared out over time..."

Provide information about mechanisms involved in cellular reparation and physiological information.

Research by NOVA medical school published in Cell Reports.

Senolytic drugs administration promotes locomotor and sensory recovery

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Cell Reports

Journal publishing research papers across a broad range of disciplines within the life sciences.

Leonor Saude

Group leader at Institute of Molecular Medicine, Universidade de Lisboa

Universidade Nova de Lisboa

Medical Sciences College since 1977 at the service of health of the future

University of Lisbon (Universidade de Lisboa, ULisboa)

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