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Hallmark of Aging Reversed by Senescent Cell Removal

25-Mar-2017

Key points from article :

Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis,

Focused on FOXO4 (Forkhead box protein O4) and its influence on p53 gene.

Senescent cells increase expression of FOXO4 to escape apoptosis.

New approach potentially has fewer side effects.

The study was published in the Cell journal.

Mentioned in this article:

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Journal

Scientific journal publishing research from many disciplines within the life sciences

Company

working with the aim to develop synthetic promoters that would be able to specifically identify senescent cells

Company

Drug development company focused on the senolytic technology to fight age-related diseases

Company

Biotechnology company devoted to research of restoring human health