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Hallmark of Aging Reversed by Senescent Cell Removal


Key points from article :

Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis,

Focused on FOXO4 (Forkhead box protein O4) and its influence on p53 gene.

Senescent cells increase expression of FOXO4 to escape apoptosis.

New approach potentially has fewer side effects.

The study was published in the Cell journal.

Mentioned in this article:

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Scientific journal publishing research from many disciplines within the life sciences


working with the aim to develop synthetic promoters that would be able to specifically identify senescent cells

Oisin Biotechnologies

Drug development company focused on the senolytic technology to fight age-related diseases

Peter de Keizer

Associate Professor at UMC Utrecht, Founder and Managing Director at Cleara Biotech

UNITY Biotechnology

Biotechnology company devoted to research of restoring human health