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Fewer mistakes in protein synthesis extends lifespan in simple microbes

14-Sep-2021

Key points from article :

Reducing naturally occurring errors in protein synthesis improves both health and lifespan.

"Mistakes in proteins are much more frequent than DNA mutations," - Ivana Bjedov, lead author.

Scientists investigated a mutation, RPS23 K60R, in the ribosomes of hyperthermophilic Archaea.

Engineered a ribosome with identical mutation and replicated its effect on protein synthesis in yeast, worms and fruit flies.

Organisms' proteins had fewer errors, as a result, became heat resistant and lived longer.

Rapamycin, torin and trametinib, known as anti-ageing drugs, can also reduce mistakes in proteins.

Cell's ability to sense nutrients can have a similar effect as calorie restriction, a known pro-longevity treatment.

"We expect our results to be extended to mammals, which could potentially lead to treatments for improved health in the elderly," - Filipe Cabreiro, Co-corresponding author .

Study by UCL and MRC published in Cell Metabolism.

Interestingly, rapamycin (and other drugs) also improves accuracy of protein production

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Journal

Scientific Journal providing information from many different areas of metabolism.

Academic

Principal Investigator at Imperial College London.

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Senior Research Fellow at UCL Cancer Institute

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Organization funding medical research in the UK.

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