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Backup code: ageing cells from epigenetic changes could potentially be reset to a youthful state


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David Sinclair is a prominent ageing researcher and is known for his book "Lifespan" and his advocacy for life extension.

Sinclair's Information Theory of Aging proposes that aging is caused by the loss of epigenetic information in cells.

Epigenetic information controls which genes are expressed and how cells function.

Suggests that a backup copy stores information about the cell’s youthful state, which could potentially reset epigenetic state. 

While the theory is intriguing, the exact location and mechanism for accessing this backup copy are still under investigation.

Believes that a "whole-body epigenetic reset" may be possible in the future.

Sinclair sees promise in senolytics, epigenetic reprogramming, and AI for future longevity interventions.

Findings in support of the theory was published in the journal Cell.

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Scientific journal publishing research from many disciplines within the life sciences

David Sinclair

Harvard professor. Author of Lifespan.

Lifespan: Why We Age―and Why We Don’t Have To


Book written by David Sinclair speaking about how to live longer and age slower

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Ageing Research interviews David Sinclair about his Information Theory of Aging and much more