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Rare genetic mutation linked to short stature may hold clues to longer, healthier lives

People with Laron syndrome exhibit lower levels of a growth factor associated with ageing

26-Apr-2024

Key points from article :

Scientists are investigating how a rare genetic mutation that causes short stature (Laron syndrome) might also increase lifespan and protect against age-related diseases.

Researchers at institutions like the University of Southern California and Albert Einstein College of Medicine, including leading experts like Nir Barzilai and Valter Longo.

This study compared 24 individuals with Laron syndrome to their unaffected relatives and focused on measures of heart health.

People with Laron syndrome have lower levels of IGF-1 (a growth factor linked to aging) and appear to have healthier hearts with reduced risk of conditions like artery plaque buildup.

This research suggests that processes related to growth factor signaling might be a target for slowing down aging and preventing diseases like cancer and cognitive decline.


Mentioned in this article:

Click on resource name for more details.

Albert Einstein College of Medicine

Center for research, medical education and clinical investigation.

University of Southern California (USC)

Private multidisciplinary research university.

Topics mentioned on this page:
Longevity Genes, Heart Disease
Rare genetic mutation linked to short stature may hold clues to longer, healthier lives