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Longevity.Technology looks at 12 key companies running age-related disease clinical trials in 2021


Key points from article :

Unity Biotechnology : senotherapeutics for eye diseases

- UBX1325 phase 1 - safe and an improvement in overall vision

Bioviva : Telomerase Reverse Transcriptase (hTERT) and Klotho gene transfer therapies

- phase 1 trials showed in increase in telomere length, biological age reduced and significant cognitive testing improvement.

CohBar : mitochondria treatments for obesity and NASH

- CB4211 phase 1a/1b - safe and led to a reduction in glucose

Denali : Parkinson’s Disease

- BIIB122 and DNL151 phase 1b - safe and achieved reductions in the biomarkers of target engagement

Scholar Rock : spinal muscular atrophy and frailty

- SRK-015/Apitegromab phase 2 - showed a meaningful motor function improvement

Biophytis : sarcopenia

- Sarconeos (BIO101) phase 2 - improvement in 400-metre walk test

Stealth BioTherapeutics : age-related macular degeneration (AMD)

- ReCLAIM-2 phase 2 - improvements in visual acuity (LLVA/BCVA)

Biosplice Therapeutics : osteoarthritis

- Lorecivivint phase 2b - safe and met primary endpoints of pain NRS (daily pain management).

- phase 3 trials already underway

Longeveron : stem cells

- Longeveron Mesenchymal Stem Cells (LMSCs) phase 2b - increase in six-minute walk test

Mesoblast : degenerative disc disease (DDD) and chronic back pain (plus a wide variety of other targets)

- Rexlemestrocel-L + Hyaluronic Acid phase 3 - effective as an opioid-paring therapy for chronic inflammatory back pain

Gensight Biologics : mitochondrial dysfunction

- LUMEVOQ (GS010) phase 3 - improvement in BCVA in Leber hereditary optic neuropathy (LHON) and retinitis pigmentosa (RP) patients

Mitotech : mitochondria-specific oxidative stress

- VISTA-1/VISTA-2 phase 3 - cleared central corneal staining (CCFS) and improved BCVA

Approaches include senotherapeutics, stem cells and mitochondria. Eye disease is a common first target.

Mentioned in this article:

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Company focused on development of therapeutics that slow the degenerative processes associated with aging.


Company focused on medical research and development for tissue-level regeneration

Bioviva Science

Gene therapy innovation leaders developing platforms to treat severe genetic disorders and cellular aging


Company focused on the research and development of mitochondria based therapeutics.

Denali Therapeutics

Company focused on the discovery and development of therapies for patients with neurodegenerative diseases

GenSight Biologics

Company focused on developing and commercializing innovative gene therapies for retinal neurodegenerative diseases


Leading regenerative medicine company located in the Life Science & Technology Park (LSTP) in Miami, Florida


Medicine company that develops biologic products for the broad field of regenerative medicine


Company developing pharmaceutical products for many age related disorders.

Scholar Rock

Company that discovers and develops a new class of biologic therapies

Stealth BioTherapeutics

Biopharmaceutical company focused on the discovery and commercialization of novel therapies..

UNITY Biotechnology

Biotechnology company devoted to research of restoring human health