Key points from article :
Mitochondria release growth differentiation factor 15 in response to mitochondrial stress.
Attenuates ageing-mediated systemic inflammatory responses in humans and mice.
High levels seen in serum and liver of elderly are associated with ageing‐induced inflammation.
Increased body weight and systemic inflammation are more frequent with low GDF15 levels.
GDF15-deficient ageing mice exhibited enhanced liver inflammation, damage, and fat deposition.
So GDF15 production in response to mitochondrial stress is a homeostatic mechanism.
Protects from ageing‐induced systemic inflammation and metabolic syndromes in humans and mice.
Research by Chungnam National University School of Medicine published in the journal Aging Cell.