Age-related changes in gut microbiota cause cognitive decline in aged rats
New study shows age-related changes to microbiome contribute to cognitive decline in aged rats.
To demonstrate, fecal microbiota transplantation (FMT) from aged to young rats done.
This shifted young rats' microbiome towards that of aged rats.
Young rats then experienced impaired cognition as a result.
FMT increased levels of pro-inflammatory cytokines and oxidative stress in young rats.
Indicates that inflammation, oxidative stress cause gut-related cognitive decline in ageing.
Also of note is the increased presence of advanced glycation end products (AGEs).
Some researchers propose that the accumulation of AGEs is a reason we age.
Study suggests cognitive impairment is the result of the age-related changes to microbiome.
And that this is mediated by chronic inflammation.
FMT is a reasonably low-tech and translatable approach to promote longevity.
Researchers from Shanxi Medical University, Taiyuan University of Technology, published in Aging.
Mentioned in this article:
Shanxi Medical University - University in Shanxi, People's Republic of China
Taiyuan University of Technology - University in Taiyuan, Shanxi province, China