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Hevolution Foundation allocates over $20 Million to promote aging research through HF-AGE grant program


Hevolution Foundation, a global non-profit dedicated to promoting research and entrepreneurship in healthspan science, has announced the recipients of its Hevolution Foundation Advancing Geroscience Efforts (HF-AGE) grants program. The program is set to award over $3.4 million in 2023, and projects a total of over $20 million by 2027. HF-AGE supports research projects that have received positive reviews from the National Institute on Aging (NIA), a part of the US National Institutes of Health (NIH), but lacked sufficient funding.

Nine research projects focusing on various aspects of aging biology and geroscience have been selected, with topics including stem cells, transcriptomics , mitochondrial dysfunction, autophagy and epigenetic age in single cells. 

HF-AGE, as an initiative from Hevolution Foundation, aims to back proposals that were well-received by NIH’s review system but didn't receive funding due to NIA's limited capacity. Hevolution Foundation's overarching mission is to extend healthy lifespan for the benefit of all humanity. The organization plans to open hubs in North America and other global locations to cultivate a global ecosystem of talent for aging and geroscience research. With an annual budget of up to $1 billion, Hevolution Foundation is working to increase the number of aging-related treatments available, expedite drug development, and enhance access to therapeutics promoting healthy lifespan, or healthspan.

Full list of recipients

Carlos Aguilar, PhD, University of Michigan at Ann Arbor, Michigan, “Understanding and engineering the relationship of muscle stem cells with the neuromuscular junction in aging”
Olga Anczukow-Camarda, PhD, The Jackson Laboratory, Farmington, Connecticut, “Building a spatial transcriptomics infrastructure for isoform profiling in aging epithelial tissues”
Holly Brown-Borg, PhD and LaDora Thompson, PhD, University of North Dakota, N. Dakota, “Cellular Mechanisms of Frailty Onset”
Sean Curran, PhD, University of Southern California, “RNA editing mediates age-related responses to mitochondrial dysfunction”
Samuel Joseph Endicott, PhD, University of Michigan at Ann Arbor, Michigan, “PTEN as a regulator of chaperone-mediated autophagy, and its effects on the lysosomal targetome”
Vadim Gladyshev, PhD, Brigham and Women’s Hospital, Boston, Massachusetts, “Profiling epigenetic age in single cells and in a high-throughput manner”
Cara Green, PhD, University of Wisconsin, Madison, Wisconsin, “The Genetic Landscape Determines the Metabolic Response to Dietary Protein”
Changhan Lee, PhD, University of Southern California, “Mitochondrial-Encoded Immunity in Aging”
Shouan Zhu, PhD, Ohio University, Athens, Ohio, “Role of protein malonylation in osteoarthritis development during aging and obesity”

Nine innovative projects, spread over seven US institutions, set to receive funding

Mentioned in this article:

Click on resource name for more details.

Brigham and Women's Hospital

Teaching hospital of Harvard Medical School.

Hevolution Foundation

Non-profit organization that funds research, Riyadh, Saudi Arabia

Ohio University

Public research university in Athens, Ohio

The Jackson Laboratory (JAX)

Independent, nonprofit biomedical research institution specialized in genetics, genomics and mouse models of disease.

University of Michigan

Public Research university.

University of North Dakota (UND)

Public research university in Grand Forks, North Dakota, the state's oldest and largest university

University of Southern California (USC)

Private multidisciplinary research university.

University of Wisconsin-Madison

Public Research university.

Hevolution Foundation allocates over $20 Million to promote aging research through HF-AGE grant program