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HTR in Drosophila somatic cells using nikase and CRISPR genetic editing tools

CRISPR genetic editing tools may be helpful in genetic repair


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A new genome editing system, developed in Drosophila, performs efficient somatic repair using intact sequences from the homologous chromosome. 

The process uses a nickase, as homologous chromosome-templated repair (HTR).

The researchers employed CRISPR genetic editing tools.

“The healthy variant can be used by the cell’s repair machinery to correct the defective mutation after cutting the mutant DNA,” said Annabel Guichard, a project scientist.

The versatility of the new system could serve as a model for fixing genetic mutations in mammals.

This work is published in Science Advances and was conducted by Ethan Bier Lab at the University of California at Santa Cruz.

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Annabel Guichard

Project scientist in Ethan Bier Lab at the University of California at San Diego (UCSD)

Science Advances

Journal that publishes original research and reviews in all disciplines of science

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Gene Therapy