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Folds in mitochondria membrane are lost as we age - reducing production of ATP


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At a certain point of age, our bodies lose the ability to make enough energy to support all the different functions.

Hazel H. Szeto, a medical doctor, found the answer to reversing the aging process by restoring a person’s ability to make energy.

Energy is produced in the form of adenosine triphosphate (ATP).

Mitochondria membrane is folded to increase the amount of surface area so that ATP can be made in a very small space.

As we age, the cristae straighten out and the ATP-making proteins can’t come together to make ATP.

Scientists found that this loss of cristae happens when we lose cardiolipin, a type of fat in blood.

Treating old mice with an antioxidant increased cardiolipin and cristae in the mitochondria of hearts and eyes.

Old mice produced just as much ATP as younger mice.

Muscles became stronger and age-related heart and eye damage was reversed.

This treatment could be the answer for many age-related diseases and injuries.

Study presented at Experimental Biology 2021.

Antioxidant treatment reversed mitochondrial ageing via cardiolipin in mice

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Hazel Szeto

Co-Founder and Director at Improving Global Health, Inc. and Scientific Founder at Stealth BioTherapeutics.

Journal of Experimental Biology (JEB)

Scientific journal covering research in the fields of comparative physiology and integrative biology.