Key points from article :
Loss of oocyte quality with age correlates with the declining levels of NAD+.
Treatment with NAD+ metabolic precursor NMN, restores it.
NAD+ replenishment has long been a target of longevity research.
Administering NMN orally in experiment resulted in “rescuing” mouse fertility.
It also increased blastocyst cell count in embryos deceloping in culture.
Works by enhancing energy metabolism, rather than by assisting sirtuins.
Notable improvements were observed in ovulation rate and in birth rates.
Researchers warn on hazards of self-treatment with NMN and other NAD+ precursors.
Published in Cell Reports.