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A novel cell therapy to reverse age related impairments

Physical fitness and immune health restored in aged mice models

06-Jul-2020

Key points from article :

Age-related frailty and immune impairments can be partially reversed in animals.

Immune cells called eosinophils in belly fat regulate chronic low-grade inflammation & ageing processes.

With age, their numbers in belly fat decline while pro-inflammatory macrophages increase.

“...transfers of eosinophils from young mice into aged recipients resolved not only local but also systemic low-grade inflammation,.." - Dr. Eggel, University of Bern.

Aged animals showed a rejuvenating effect on the physical fitness and immune system.

Age-related changes in adipose immune cell distribution in mice were also confirmed in humans.

Research by University of Bern published in Nature Metabolism.

Mentioned in this article:

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Alexander Eggel

Investigator at the Department of Rheumatology, Immunology and Allergology at the University Hospital Bern

Nature Metabolism

Online journal Nature Metabolism is an online journal of Nature Research

University of Bern

Public research university.

Topics mentioned on this page:
Immunosenescence, Inflammaging