Key points from article :
Composition and diversity of gut microbiome (GM) changes come with ageing.
One hypothesis: these could potentially be the origin point of inflammaging.
It is the chronic low-grade smoldering background of inflammation, in old people.
Studied these changes in C57BL/6 (Black 6) mice.
Mice fed a 45% high-fat diet (HFD) for 10-20 period have increased Actinobacteria.
Actinobacteria levels are typically higher in obese individuals.
HFD, closely linked with body weight and presence of proinflammatory cytokines (PF).
Ageing, seen to increase Firmicutes in GM as did the presence of PF.
Bacteroides observed to decrease with ageing, while PF in colon rise.
Both ageing and a high-fat diet cause significant changes to the microbiome.
Published in BMC Microbiology.
