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Mitochondria plays a major role in cellular ageing


Key points from article :

Mitochondria communicates with nucleus and trigger senescence causing cellular ageing.

An FDA-approved drug currently used to treat cancer can restore senescent cells to their youth.

HDAC inhibitor-treatment caused less inflammatory signals and better mitochondrial function.

But it's too toxic to use in healthy individuals just to prevent disease.

This study firmly links dysfunctional mitochondria, inflammation and senescent cells to ageing.

Needs to screen for less toxic senescence-inhibiting drugs.

A collaborative research published in Genes & Development.

HDAC inhibitor shows beneficial effects in mice but too toxic for healthy humans

Mentioned in this article:

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Genes & Development

Publishes research in molecular biology, genetics, cancer biology, biochemistry

Glenn Foundation For Medical Research

The mission of the Glenn Foundation For Medical Research is to extend the healthy years of life

Harvard University

Private Ivy League research university in Massachusetts

Mark R Collins

President of Glenn Foundation for Medical Research

Peter D. Adams

Co-Director Aging, Cancer and Immuno-oncology at SBP, Co-Editor-in-Chief Aging Cell

Sanford Burnham Prebys Medical Discovery Institute

Conducts collaborative research to find new therapies and improve quality of life