Join the club for FREE to access the whole archive and other member benefits.

Biological age reversed with growth hormone and diabetes drugs cocktail

Small, uncontrolled trial, but (potentially) very exciting results


Key points from article :

Trial was designed restore tissue in the thymus gland using growth hormone.

This hormone can also promote diabetes, so the trial included two anti-diabetic drugs.

Dehydroepiandrosterone (DHEA) and metformin are widely used. Nine healthy volunteers took the drug cocktail for one year.

Participants, on average, shed 2.5 years of their biological ages based on their epigenetic clocks. T

he effect persisted six months after stopping the trial.

Blood-cell count was rejuvenated and thymus tissue regenerated.

Expansion of immune cells also has implications infectious disease and cancer.

Thymus Regeneration, Immunorestoration and Insulin Mitigation (TRIIM) trial being run by Intervene Immune.

Findings by University of California, Los Angeles, were published in Aging Cell.

Caution warned: trial was small and did not include a control arm.

Mentioned in this article:

Click on resource name for more details.

Aging Cell

Scientific journal devoted to age related diseases

Greg Fahy

World expert in organ cryopreservation, Chief Scientific Officer and Co-founder at Intervene Immune

Intervene Immune

Company focused on the age-related decline of the immune system, which is known as immunosenescence

Steve Horvath

Professor of Human Genetics & Biostatistics at UCLA

University of California

Public research university with 10 campuses and 5 medical centres

Topics mentioned on this page:
Metformin, Regenerative Medicine
Biological age reversed with growth hormone and diabetes drugs cocktail