Key points from article :
Calorie restriction has life extending benefit but achieving such a diet is challenging.
Reduction in core temperature contributes to the diet’s beneficial effects.
Chemicals that might contribute to these health benefits were identified.
Compared metabolites of mice housed at 22°C with those in 30°C - both on calorie restricted diet.
At 30°C, the bodies of both mice and humans reach “thermoneutrality.”
Thermoneutral conditions reduce some of the health benefits of calorie restriction.
Calorie restriction led to the production of a range of metabolites at 22°C — but not at 30°C.
Two metabolites that stood out were nitric oxide and an opioid called leucine enkephalin.
This will help develop a drug that could mimic the benefits of calorie restriction.
Study. by The Scripps Research Institute published in Science Signaling.