Key points from article :
Research to identify traits, lifestyle factors associated with different ageing trajectories.
Epigenetic clock, DNAm PhenoAge, aimed to capture a more precise biomarker.
That can differentiate morbidity, mortality among individuals of same chronological age.
Hypothesis: Childhood traits, IQ level impact epigenetic age (EA) and reflect in PhenoAGe results.
To investigate this, The Lothian Birth Cohort 1936 was reexamined and used.
Participants’ genetic variants observed to see if they are associated with any traits.
Results: Accelerated EA was related to lower IQ scores at 11.
As well as lower levels of physical activity later in life.
Association between PhenoAge with IQ measured almost 60 years previously, a key finding.
It is indicative of lifelong, enduring association between cognition and epigenetic ageing.
Confirmed association between childhood intelligence, life-course differences in health and morbidity.
Published in Translational Psychiatry.
