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Oral senolytics boosts geroprotective protein in mice and humans

Dasatinib+Quercetin restores a-klotho protein, which could combat ageing and disease in older people


Key points from article :

Senolytic drugs can boost a key protein in the body that may protect older people against aging and a range of diseases.

Senolytics given once clear the bloodstream of senescent or "zombie" cells.

Removal of senescent cells significantly boosts the production of a protective protein called a-klotho.

" orally active, small-molecule approach to increase this beneficial protein and also to amplify senolytic drugs," - James Kirkland, senior author of the study.

Using desatinib plus quercitin in 3 types of mice and patients with idiopathic pulmonary fibrosis, a-klotho is increased.

"...first to link the potential impact of fat-resident senescent cells on brain a-klotho," - Yi Zhu, first author of the study.

Protein a-klotho is important to maintaining good health, as it tends to decrease with age, especially in multiple diseases.

In mice, decreasing a-klotho shortens life span and increasing a-klotho increases life span by 30%.

Research by Mayo Clinic published in eBioMedicine.

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Medical journal covering all fields in the biomedical research

James Kirkland

Researcher on different aging related diseases

Mayo Clinic

Non-profit American academic medical center focused on health care, education, and research

Yi Zhu

Assistant Professor at Mayo Clinic.

Topics mentioned on this page:
Senescent Cells