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Mammalian brain cells mapped for better understanding of the neuronal disorders

06-Oct-2021

Key points from article :

The NIH Brain Initiative (BICCN) published a map of cell types and neuronal wiring for the mammalian primary motor cortex.

An account of the cells types and how they differ from each other are important for understanding brain disorders.

"Research conducted..will help provide tools that enable precise targeting of cell types and neural networks by genomic therapy" - Walter Koroshetz, director, NIND.

BICCN researchers catalogued different cells of the mammalian primary cortex, involved in controlling complex movement.

Different brain cell types were characterized using a combination of electrophysiological, morphological, and circuit tracing approaches.

Single-cell transcriptome and epigenomes were also analyzed to identify unique gene markers defining cell types in the primary motor cortex.

Similar cell types across mice, monkeys, and humans were identified, with differences in gene expression responsible for variations in the way the three species process neural information.

"...This work represents a crucial step that will dramatically enhance the pace of advances in understanding the brain,” Joshua. G, Director, NIMH.

Study conducted by members of BRAIN Initiative Cell Census Network (BICCN) published in Nature.

The atlas of the brain cells developed will help pave the way for future research in brain disorders

Mentioned in this article:

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Academic

Deputy Director of NIH Brain Initiative

Academic

American physician-geneticist & the director of National Institutes of Health (NIH) since 2009

Academic

Director of the National Institute of Mental Health

Institute

Federal agency for research on mental disorders

Institute

Seeks knowledge about the brain and nervous system and reduce the burden of neurological disease

Academic

Director of National Institute of Neurological Disorders and Stroke (NIND)