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A novel gene editing tool to fight aggressive cancers

18-Nov-2020

Key points from article :

A lipid nanoparticle-based delivery system ( CRISPR-LNPs) can target & kill cancers by genetic manipulation.

Carries messenger encoding for CRISPR enzyme that act as molecular scissors & cut the cells' DNA.

"First study... to prove that CRISPR can be used to treat cancer in a living animal," - Prof. Peer, TAU.

"..This is not chemotherapy. There are no side effects, and a cancer cell treated in this way will never become active again."

The technology was tested to treat deadly cancers- glioblastoma and metastatic ovarian cancer.

Treatment improved the overall survival rate by about 30% and 80% respectively in mice.

However, clinical implementation is still in its infancy.

"An innovative treatment for aggressive cancers that have no effective treatments today" - Prof. Peer.

Can be used in other types of cancer, rare genetic diseases and chronic viral diseases such as AIDS.

Research by Tel Aviv University published in Science Advances.

Uses CRISPR technology to target and destroy cancer cells

Mentioned in this article:

Academic

Professor and the Director of the Laboratory of Precision NanoMedicine at Tel Aviv University

Journal

Scientific Journal

Academia

Public Research university.