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Small Mayo Clinic trial successfully removes senescent cells from humans

Occasional senolytic use may be enough to keep senescent cells at bay


Key points from article :

Senescent cells can be removed from the body using senolytics drugs.

First trial to show that senolytic drugs can remove senescent cells from humans.

For three days, nine participants received a combination dose of dasatinab and quercetin.

The drugs cleared the body in a couple of days.

Effects on reducing senescent cells were evident for at least 11 days.

Results of occasional dosing reduces risks from having to give drugs continuously.

Senescent cells are characteristic in end-stage kidney failure as well as diabetes-related kidney disease.

Mayo Clinic research appears in the journal EBioMedicine.

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Medical journal covering all fields in the biomedical research

James Kirkland

Researcher on different aging related diseases

Ronald Kohanski

Deputy Director of the Division of Aging Biology at the National Institute on Aging.

Topics mentioned on this page:
Senescent Cells