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SENISCA to reverse senescence by targeting RNA splicing patterns


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SENISCA’s Co-founder Lorna Harries talks oligos, splicing and skin aging at the fourth annual Longevity Leaders World Congress.

- Rejuvenating senescent cells, rather than clearing them, but it depends on the end goal.

- In cell poor tissues or sites, you need to preserve tissue integrity, a senomorphic approach might be better.

- We can rejuvenate and attenuate the SASP without inducing the cells to divide, because they may have features of ageing.

- Evidence for dysregulation of splicing to be classified as a hallmark of ageing.

- Small molecules or oligonucleotides to block interactions at genes and processes that affect signalling pathways.

- More advantages if the target genes are known.

- Oligos can be used at very low doses, with exquisite specificity; off target effects are much rarer.

- Conjugate oligos to targeting proteins, or targeted nanoparticles which can deliver directly to the cells of interest.

- Can used oligos systemically or locally with little or no distribution to other organs.

Lorna Harries details significant breakthroughs at fourth annual Longevity Leaders World Congress

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Professor of Molecular Genetics at the University of Exeter.


University of Exeter spinout aiming to develop senotherapeutic interventions