Key points from article :
SENISCA’s Co-founder Lorna Harries talks oligos, splicing and skin aging at the fourth annual Longevity Leaders World Congress.
- Rejuvenating senescent cells, rather than clearing them, but it depends on the end goal.
- In cell poor tissues or sites, you need to preserve tissue integrity, a senomorphic approach might be better.
- We can rejuvenate and attenuate the SASP without inducing the cells to divide, because they may have features of ageing.
- Evidence for dysregulation of splicing to be classified as a hallmark of ageing.
- Small molecules or oligonucleotides to block interactions at genes and processes that affect signalling pathways.
- More advantages if the target genes are known.
- Oligos can be used at very low doses, with exquisite specificity; off target effects are much rarer.
- Conjugate oligos to targeting proteins, or targeted nanoparticles which can deliver directly to the cells of interest.
- Can used oligos systemically or locally with little or no distribution to other organs.