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Eating less, living longer: the positive effects of calorie restriction

16-Oct-2023

Key points from article :

Calorie restriction, as studied by the National Institutes of Health (NIH), may boost muscle strength and activate ageing-delaying genes. (Published in Aging Cell)

The study focused on data from the CALERIE project, where participants aimed for a 25% calorie reduction but achieved a 12% reduction.

Dr. Luigi Ferrucci, NIA Scientific Director, emphasised the modest reduction's significant health impact.

Despite muscle mass loss, calorie restriction participants maintained muscle strength, enhancing muscle specific force.

Thigh muscle biopsies and mRNA analysis revealed that calorie restriction impacted genes responsible for energy generation and reduced inflammation.

This approach shows promise in preventing age-related inflammation and promoting healthier ageing.

Modest calorie reduction can activate genes for healthy ageing

Mentioned in this article:

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Aging Cell

Scientific Journal devoted to age related diseases.

Luigi Ferrucci

Scientific Director at the National Institutes of Aging (NIA)

National Institutes of Health (NIH)

Medical research agency that supports scientific studies

Eating less, living longer: the positive effects of calorie restriction