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Catalysis of TET1 - necessary for myelin repair in young adults

08-Jun-2021

Key points from article :

Progressive decline in myelin is linked to cognitive and motor deficits in older people.

Sarah Moyon, research assistant professor and the study’s lead author says

"We found that TET1 levels progressively decline in older mice

and DNA can no longer be properly modified to guarantee the formation of functional myelin"

Patrizia Casaccia, professor of biology and biochemistry at GC/CUNY, and the study’s primary investigator says

"... We used a newly developed method—reduced representation hydroxymethylation profiling..."

Authors show TET1 catalyzed DNA hydroxylation target genes facilitating proper function of neurons and glia.

Newly identified age-related decline in TET1 may account for the inability of older individuals to form new myelin.

The study has important implications for molecular rejuvenation of aging brains in healthy individuals.

Research by Advanced Science Research Centre published in Nature Communications.

Regulation of adult remyelination in mice by TET1-mediated DNA hydroxymethylation

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Building a world-class research enterprise at the greatest urban university in the world

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Works at CUNY ASRC and Mount Sinai School of Medicine, New York

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Research Assistant Professor, Casaccia Lab, Neuroscience Initiative at ASRC-CUNY