Key points from article :
Non human model organisms appear to guard against long lived individuals.
Zhengdong Zhang, corresponding author says "Rare variants in aging pathways affect human lifespan and constitute a part of the genetic architecture of human longevity".
Researchers sequenced exomes of 515 centenarians of Ashkenazi Jewish ancestry and 496 non-centenarians controls.
Uncovered 130,300 rare SNPs or small insertions considered for association analyses.
Researchers Identified rare genetic variants enriched in centenarians and possibly related to their extreme longevity.
With large effect sizes to develop the drug targets needed for combating age-related multi morbidity.
They noted that rare variants found in specific pathways are linked to past studies.
Rare variants detected in the conservative pathways are protective against age-related pathology.
They saw an uptick in rare variants centered on insulin and insulin-like growth factor 1.
Research by Albert Einstein College of Medicine published in Nature Aging.
