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Telomeres encode two novel signaling proteins may change our understanding of cancer and aging

Blood tests for proteins encoded by telomeres could give information of biological age and cancer

20-Feb-2023

Key points from article :

Telomeres contain genetic information to produce two small proteins, one of which they found is elevated in some human cancer cells.

"Based on our research, we think simple blood tests for these proteins could provide a valuable screen for certain cancers and other human diseases," said Jack Griffith, researcher.

"These tests also could provide a measure of 'telomere health,' because we know telomeres shorten with age." He added.

"As we age, the amount of VR(valine-arginine) and GL(glycine-leucine) in our blood will steadily rise, providing a new biomarker for biological age," said Taghreed Al-Turki, co-author.

The biggest priority now is developing a simple blood test for these proteins. 

This could inform us of our biological age and also provide warnings of issues, such as cancer or inflammation.

Reported in the Proceedings of the National Academy of Sciences and the study was carried out at UNC School of Medicine.

Mentioned in this article:

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Jack Griffith

Distinguished Professor, Microbiology and Immunology, Biochemistry and Biophysics at UNC school of medicine

National Academy of Sciences (NAS)

Non-profit organization of the America's leading researchers

Taghreed AlTurki

Postdoctoral researcher in the Griffith lab at UNC

UNC School of Medicine

University of North Carolina public school of medicine.

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Telomeres
Telomeres encode two novel signaling proteins may change our understanding of cancer and aging