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ECM proteins help to develop more robust methods for generation of heart cells


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Lab-grown human heart cells provide a powerful tool to understand and potentially treat heart disease but methods are not optimal.

The role of extracellular matrix (ECM) proteins in the generation of heart cells derived from human pluripotent stem cells (hPSCs) have been investigated.

With a better understanding of ECM, researchers will be able to  develop heart muscle cells, called cardiomyocytes.

“By understanding the roles of ECM, this study will help to develop more robust methods and protocols for generation of hPSC-CMs,” says Jianhua Zhang, a senior scientist.

The next step could be using hPSC-cardiomyocytes for disease modeling, drug screening, cardiac regeneration and cell therapy.

Research carried at the University of Wisconsin–Madison Stem Cell & Regenerative Medicine Center and published in eLife.

ECM proteins play significant roles in hPSC adhesion, growth & cardiac differentiation

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eLife Sciences

Non-profit journal publishing work in all areas of biology and medicine

Jianhua Zhang

Senior scientist, Cardiovascular Medicine, University of Wisconsin–Madison

University of Wisconsin-Madison

Public Research university.