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Highlights from eLife's Aging, Geroscience and Longevity Symposium

17-Dec-2020

Key points from article :

Peter Fedichev - GERO

Burden of rarest protein-truncating variants (PTVs) is negatively associated with human lifespan, accounting for 1.3 years variability.

Sara Hägg - Karolinska Institutet

Developed nine measurements of biological age.

Dario Riccardo Valenzano - Max Planck Institute for Biology of Ageing

Limited population size ... exacerbates the effects of mutation accumulation and cumulatively contribute to short adult lifespan.

Jonathan An - University of Washington

Bridging the interface of aging biology and oral biology to extend the oral healthspan in people.

Mounir El Maï - IRCAN

Inhibition of FoxO transcription factors by Akt indirectly induce p15/16 growth arrest and senescence.

Morgan Levine - Yale School of Medicine

Reduced representation bisulfite sequencing (RRBS) data was used to train an epigenetic age (DNAmAge) measure in rats.

Dudley Lamming - University of Wisconsin-Madison

Ovariectomized female mice have improved survival despite increased adiposity and decreased control of blood glucose levels.

Amanda Kowalczyk - Carnegie Mellon University – University of Pittsburgh

Pan-mammalian analysis finds that effective cancer control is a key adaptation underlying the evolution of extreme longevity.

Michael Polymenis - Texas A&M University

Loss of one-carbon (1C) enzymes increased the longevity of wild type cells.

Nicole Jenkins - University of Melbourne

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging C. elegans.

Hosni Cherif - McGill University

Potential of senolytic compounds to remove senescent intervertebral disc (IVD) cells, reducing the inflammatory environment and pain.

Fivos Borbolis - Academy of Athens

Critical and conserved function of DCAP-1/DCP1 in lifespan modulation and control of developmental events.

Ying Ann Chiao - Oklahoma Medical Research Foundation

Mitochondrial-targeted peptide SS-31 (elamipretide) can substantially reverse pre-existing cardiac dysfunction in old mice.

Authors covered biological age clocks, senescent cells, longevity genes, and more

Mentioned in this article:

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Academic

Ph.D. Candidate in Computational and Systems Biology at the University of Pittsburgh.

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Group leader at the Max Planck Institute for Biology of Ageing.

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Associate Professor Of Medicine at University of Wisconsin-Madison.

Journal

Non-profit journal publishing work in all areas of biology and medicine

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Postdoctoral Researcher at Biomedical Research Foundation of the Academy of Athens.

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Postdoctoral Fellow at McGill University.

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Assistant Professor at University of Washington School of Dentistry.

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Professor of Biochemistry & Biophysics at Texas A&M University.

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Founding Principal Investigator at Altos labs, Authored True Age book

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Post-Doctoral Researcher at Institute for Research on Cancer and Aging, Nice.

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Senior Research Officer at Florey Institute of Neuroscience and Mental Health.

Company Representative

Founder of Gero and physicist in drug discovery land.

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Associate Professor in Molecular Epidemiology at Karolinska Institutet.

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Assistant Member at Oklahoma Medical Research Foundation.